Shifts in the clonal distribution of methicillin-resistant

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A clonal outbreak of methicillin-susceptible ...

In contrast to methicillin-resistant Staphylococcus aureus (MRSA), studies on clonal distribution of methicillin-susceptible S. aureus (MSSA) are scarce. Since 2004, an increasing incidence of concomitant resistance to erythromycin, clindamycin and tobramycin (ECT) among MSSA has been detected in Östergötland County, Sweden.

Antimicrobial Resistance and Molecular Analysis of ...

Clonal distribution of methicillin-resistant Staphylococcus aureus (MRSA) in hospitals may differ according to the geographic location and time period. Knowledge of MRSA clonal epidemiology in hospital settings involves much more than the study of healthcare-associated MRSA (HA-MRSA) clones.

Molecular tracing of the emergence, adaptation, and ...

Hospital-associated infections caused by methicillin-resistant Staphylococcus aureus (MRSA) are a global health burden dominated by a small number of bacterial clones. The pandemic EMRSA-16 clone (ST36-II) has been widespread in UK hospitals for 20 y, but its evolutionary origin and the molecular basis for its hospital association are unclear.

Distribution of the Most Prevalent Spa Types among ...

The following data were extracted from each article: first author's name, year of publication, country, number of isolates, number of methicillin resistant and susceptible S. aureus isolates (MRSA and MSSA), the predominant spa type, SCCmec types of the predominant spa types, MLST and spa clonal complexes belonging to the most prevalent spa types.

Molecular characterization of methicillin-resistant ...

Molecular characterization of methicillin-resistant Staphylococcus aureus in ... TABLE 1. Distribution of MRSA clonal complexes Clonal complex Strain affiliation Total CC1 CC1-MRSA-IV, WA MRSA-1/57 1 ... confirm that a shift has occurred, with what are presumably

Shifts in the Clonal Distribution of Methicillin-Resistant ...

Shifts in the Clonal Distribution of Methicillin-Resistant Staphylococcus aureus in Kuwait Hospitals: 1992-2010 ... Background As the epidemiology of methicillin-resistant Staphylococcus aureus ...

Evolutionary dynamics of methicillin-resistant ...

In the past decade, several countries have seen gradual replacement of endemic multi-resistant healthcare-associated methicillin-resistant Staphylococcus aureus (MRSA) with clones that are more susceptible to antibiotic treatment. One example is Singapore, where MRSA ST239, the dominant clone since molecular profiling of MRSA began in the mid-1980s, has been replaced by ST22 isolates

Clinical features and molecular characteristics of ...

Clinical features and molecular characteristics of childhood community-associated methicillin-resistant Staphylococcus aureus infection in a medical center in northern Taiwan, 2012

Population Genetic Structure of the Staphylococcus ...

A lack of clonal association of agr alleles suggests that assortive recombination may have contributed to the distribution of agr diversity. Finally, we discovered that the recent emergence of methicillin-resistant strains was due to multiple acquisitions of the mecA gene by different S. pseudintermedius clones found on different continents.

High genotypic diversity among methicillin-resistant ...

Background. Methicillin-resistant Staphylococcus pseudintermedius (MRSP) has emerged globally in companion animals in the last decade. In Europe, the multidrug-resistant sequence type (ST)71 is widespread, but recently other clones have appeared.

Global Distribution of Panton-Valentine Leukocidin ...

We determined the agr type, multilocus sequence type, protein A gene type (spa typing), toxin gene profile, and antimicrobial drug resistance profile of 469 isolates of Panton-Valentine leukocidinpositive community-acquired methicillin-resistant Staphylococcus aureus isolates (PVL-positive CA-MRSA). The isolates had been collected from around the world from 1999 through 2005 by the French National

Automated categorization of methicillin-resistant ...

Fig. 2. Two-dimensional peak distribution diagrams displaying the paired distribution for the best separating peaks in the supervised neural network model; the ellipses represent the standard deviation of the class average of the peak areas/intensities.

Replacement of methicillin-resistant Staphylococcus aureus ...

Fig. 1. Comparison of the geographical distribution of the major methicillin-resistant Staphylococcus aureus clones in Hungary during 19941998 and 20012004. The Hungarian clone (ST239-III) is represented by circles, the Southern German clone (ST228-I) by triangles, and the New YorkJapan clone (ST5-II) by squares.

Shifts in the Clonal Distribution of Methicillin-Resistant ...

Shifts in the Clonal Distribution of Methicillin-Resistant Staphylococcus aureus in Kuwait Hospitals: 1992-2010 Authors: Boswihi, Samar S. ; Udo, Edet E. ; Al-Sweih, Noura

Clonal distribution and possible microevolution of ...

Escalation of methicillin-resistant Staphylococcus aureus (S. aureus) (MRSA) infections have been noted in Malaysia with a high incidence rate observable in surgical or orthopedic wards, pediatric wards and intensive care units,.

Widespread Skin and Soft-Tissue Infections Due to Two ...

Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of hospital-acquired infection worldwide. Hospital-associated MRSA strains are typically resistant to multiple antibiotics, compounding the challenge of finding effective treatment options.

Clonal diversity and geographic distribution of ...

Abstract. Methicillin-resistant Staphylococcus pseudintermedius (MRSP) is an increasingly prevalent pathogen in veterinary medicine. This study examined the molecular epidemiology of clinical MRSP isolated from Australian animals.

Frequency, antimicrobial susceptibility and clonal ...

In the last decade there has been a rapid global spread of methicillin-resistant Staphylococcus pseudintermedius (MRSP) clones displaying multidrug resistance in dogs. We investigated prevalence, antimicrobial susceptibility and clonal distribution of MRSP isolated from clinical canine samples between during 20112014.

Methicillin-resistant Staphylococcus aureus: An update on ...

Methicillin-resistant Staphylococcus aureus (MRSA) is a major pathogen in hospitals and the community. In the past, most of the infections caused by MRSA were confined to elderly patients in healthcare facilities and they were described as healthcare-associated MRSA (HA-MRSA).

Clonal Heterogeneity, Distribution, and Pathogenicity of ...

Figure 1 : Distribution of methicillin-resistant Staphylococcus aureus (n = 110) and methicillin-sensitive Staphylococcus aureus (n = 2091) among specimens from different sources, *p < 0.05. DNA fragments ranging flom 40 to 700 kb. Gels were stained with ethidium bromide and

Frontiers Dissimilar Fitness Associated with Resistance ...

Fitness cost associated with resistance to fluoroquinolones was recently shown to vary across clones of methicillin-resistant Staphylococcus aureus and extended-spectrum β-lactamase-producing Klebsiella pneumoniae. The resulting dissimilar fitness should have influenced the clonal dynamics and thereby the rates of resistance for these pathogens.

Methicillin-resistant Staphylococcus ... - Genome Biology

Methicillin-resistant Staphylococcus aureus (MRSA) has been identified as one of the major risk pathogens associated with the development of antimicrobial resistance (AMR). The emergence of AMR in S. aureus is well documented and the species has proven particularly adept at evolving resistance in the face of new antibiotic challenges.

Increase in prevalence of PVL and clonal shift in ...

The lognormal distribution is often applied to occupational exposures, yet the assumption of lognormality is rarely verified. This lack of rigor in evaluating the appropriateness of the lognormal model has resulted, in part, from the difficulty of applying formal goodness-of-fit tests.

Clonal distribution of methicillin-resistant ...

Testing the efficacy of a HeMRSA clonal type I::NH::A isolates, which are widespread molecular surveillance network: methicillin-resistant Staphylococcus aureus in Warsaw, were present in the same hospital (WAW2) over a (MRSA) and vancomycin-resistant Enterococcus faecium (VREF) genotypes period of at least 5 years.

Increasing Prevalence of Methicillin-Resistant ...

Annual distribution of MRSA in isolates obtained from the population of the San Francisco County jail system. The line graph indicates the percentage of MRSA among all S. aureus isolates. The bar graph indicates the proportions of MRSA isolates associated with different clonal groups.

Shift in dominant hospital-associated methicillin ...

Methicillin-resistant S. aureus (MRSA) are prevalent in hospitals and have acquired the mecA gene on genetic cassettes called SCCmec. 5 This renders them resistant to nearly all β-lactamase-resistant β-lactams, including methicillin, flucloxacillin, carbapenems and cephalosporins.

Origins and Evolution of Methicillin-Resistant ...

Surveillance of methicillin-resistant Staphylococcus aureus in a pediatric hospital in Mexico City during a 7-year period (1997 to 2003): clonal evolution and impact of infection control. J. Clin. Microbiol. 42: 3877-3880.

Clonal Distribution of Methicillin-Resistant ...

We report on a study of 158 methicillin-resistantStaphylococcus aureus (MRSA) clinical isolates obtained from 1990 to 1996 in 18 different hospitals in Poland. All isolates were recovered from infection and carriage sites of patients, carriage sites of health care personnel, and hospital environment samples.

Clonal Distribution of Methicillin-Resistant ...

PDF We report on a study of 158 methicillin-resistant Staphylococcus aureus (MRSA) clinical isolates obtained from 1990 to 1996 in 18 different hospitals in Poland.

Methicillin Resistant Staphylococcus aureus

Methicillin-resistant S. aureus strains have acquired resistance to methicillin and other beta lactam antibiotics (e.g., penicillins and cephalosporins) via the mecA or mecC genes.

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